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Abstract Multiple primary tumors can be synchronous when detected simultaneously or metachronous when detected after a variable time interval. We present the case of a year-old female patient with a history of keratinized squamous cell carcinoma of the cervix, stage T3bNxMx, operated, and treated by chemotherapy and radiation therapy which develops after three years a large cell neuroendocrine carcinoma of the lung detected by imaging. Of major importance in the selection of the optimal therapeutic approach was the accurate determination of the histological type of the metachronous tumor by microscopy and immunohistochemical techniques.

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Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances Neuroendocrine cancer organizations The incidence of GEP-NENs has increased worldwide neuroendocrine cancer organizations the past decades, with the small intestine, rectum, and pancreas as the most common tumor locations. Lung Neuroendocrine Tumors: Imaging and Diagnosis with Robert Ramirez, OD The epidemiological characteristics, pathogenesis and treatment have raised many questions, and some of them are still being debated. Here, we report a case of gastric collision tumor with large-cell neuroendocrine carcinoma and adenocarcinoma.

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